After a long
and, for Anja and Zouhair an eventful flight from Germany to Philadelphia, we
arrived to our destination for the PlaqOmics meeting (13-15 Nov).
On the
first day, there were many great talks with the focus on single cell RNA sequencing
of atherosclerotic plaques in both human and mice. Moreover, we discussed the
role of athero-promoting transitions in vascular smooth muscles cells as well as
endothelial cells in the late stage of atherosclerosis. The meeting ended on
the second day with a great talk by Prof. Heribert Shunkert who walked us
through GWAS through the years and a multiplicative model of risk alleles for
complex traits but with no epistasis effect which was followed by a great
post-presentation discussion. An interesting, and tentatively provocative
part of the discussion veered towards possible therapy application, and the
implication of the non-epistasis multiplicativity characteristic proposed
during the talk.
LMV, AT, ZA,
TR
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