Sometimes you win, sometimes you loose

During the last 14 days we experienced up and downs at the IIEG; it was like on a roller coaster. 
First, we published a paper in the prestigious New England Journal of Medicine about mutations in the angiopoietin-like 4 (ANGPTL4) gene which are associated with coronary artery disease (CAD).
Actually, we found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease. The paper can be found here

Second, we co-authored a paper published in Science last week about mutations in SCARB1, HDL levels and risk for coronary artery disease. An informative article about the background of this story can be found here.

Than, on late friday afternoon we got, absolutely surprising and (until April unofficially) bad news: one of our large projects will not be extended. 

It is really hard to get over this. However, as I always tell my (MD and PhD) students: as a scientist you need to have a very high level of tolerance for frustration.