Sometimes it takes more than half a century to get to the point (at least partially).
In 1951, Paul Dudley White (the ‘father’ of American cardiology) published a paper in JAMA, often described as the first case-control study for MI (100 with MI prior to age of 40 and 147 free of MI).
He and his colleagues reported the association of shorter stature with increased risk for MI. The cases were 2 inches shorter than controls.
The paper is a fascinating read and provides historical context of our collective efforts to understand the etiology of MI.
In 1951, Paul Dudley White (the ‘father’ of American cardiology) published a paper in JAMA, often described as the first case-control study for MI (100 with MI prior to age of 40 and 147 free of MI).
He and his colleagues reported the association of shorter stature with increased risk for MI. The cases were 2 inches shorter than controls.
The paper is a fascinating read and provides historical context of our collective efforts to understand the etiology of MI.
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| JAMA 1951 |
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| JAMA 1951 |
Today, 60 years later, Nilesh Samani, on behalf of our CARDIoGRAMplusC4D consortium, reports in the New England Journal of Medicine, a somewhat deeper understanding of this association.
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| NEJM 2015 |
We found a primary association between a genetically determined shorter height and an increased risk of CAD/MI. We must keep in mind that association does not imply causality per se.
Here the association can partly be explained by the association between shorter height and an adverse lipid profile.
Furthermore, based on the genetic data we have identified some shared biologic processes that determine achieved height and the development of atherosclerosis which may explain some of the association.
This was a great and inspiring collaborative effort involving dozens of colleagues and hundred thousands of people willing to participate in genetic studies.
Looking forward to conduct more such fascinating studies.
JE
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